Hyaluronic Acid act as a Non - Invasive Marker for Diagnosis of Liver Fibrosis in the Patients of Chronic Hepatitis C
Keywords:
Hyaluronic acid, Liver fibrosis, Hepatitis CAbstract
OBJECTIVE: To evaluate the biochemical significance of Hyaluronic acid in liver fibrosis among
chronic hepatitis C patients to eliminate repetitive liver biopsies.
METHODOLOGY: Cross Sectional Comparative Analytical Study at FPGMI, Shaikh Zayed
Hospital, Lahore from January 2017 to December 2017. This cross-sectional study, included patients of
chronic hepatitis C (n = 250) along with controls (n =100). Serum hyaluronic acid assay (patients &
controls) was performed using enzyme linked binding protein assay, using a capture molecule known
as hyaluronic acid binding protein (HABP) along with quantitative Echelon (Echelon biosciences Inc.
USA) used as reference standard.
RESULTS: Total 350 participant both male and females participated for this study from these 350
samples, 100 normal samples were recruited as control group and 250 diagnosed cases of chronic
hepatitis C patients were recruited as case study group. Serum Hyaluronic acid was significantly
(P<0.001) elevated in patients (195.77 ±6.67) compared to controls (110.2 ±0.79) irrespective of gender
involvement.
CONCLUSION: The current findings showed significant involvement of HA in early prognosis of liver
fibrosis and cirrhosis among chronic HCV patients that would probably useful to reduce repetitive liver
biopsy.
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