Role of Oxidative Stress in Various Stages of Psoriatic Patients

Authors

  • Feroz Khan
  • Muhammad Akram
  • Azizur Rehman
  • Mehreen .
  • Jahanzaib .
  • Syed Muhammad Naeem

Abstract

Objective: To Assess the Role of Antioxidant, Lipid Peroxidation Status and Lipid Profile in various stages of Psoriasis Patients.

Methodology: The present study was a Case Control. It was carried out in the Department of Biochemistry, at Basic Medical Sciences Institute (BMSI) Jinnah Post Graduate Medical Centre from April - December 2015. One hundred and twenty cases of psoriasis patients grouped as Mild, Moderate, Severe and Forty healthy control for comparison was included in the study.

Lipid Profile including serum total cholesterol, Triglyceride (TG), - high density lipoproteins (HDL) and low- density lipoproteins (LDL), were estimated by enzymatic colorimetric Method on Micro lab 300 (Merck & Germany) and Antioxidant status like Superoxide Dismutase (SOD) and Lipid Peroxidation status like Malondialdehyde (MDA) were measured by ELISA. The statistical analysis was performed by SPSS software Version 16. P value less than 0.005 was considered significant.

Results: Our result showed significantly increase in the mean serum level of triglycerides (TG), Total Cholesterol and low density lipoproteins in psoriatic patients when compared to control where as high density Lipoproteins was significantly decline in psoriatic groups when compared to control while SOD level was reduced in psoriasis patients as compared to control. The MDA level was raised in psoriasis patients as compared to control.

Conclusion: The finding of our study support the hypothesis that imbalance in oxidant-antioxidant system play role in the etiology of psoriasis. Also dyslipidemia was observed risk factor for development of cardiovascular diseases.

 Keywords: Oxidative Stress, Psoriasis

Downloads

Published

07-10-2020

How to Cite

1.
Khan F, Akram M, Rehman A, . M, . J, Naeem SM. Role of Oxidative Stress in Various Stages of Psoriatic Patients. J Liaq Uni Med Health Sci [Internet]. 2020 Oct. 7 [cited 2024 Nov. 5];19(03):177-80. Available from: http://ojs.lumhs.edu.pk/index.php/jlumhs/article/view/400

Issue

Vol. 19 No. 03 (2020): Journal of Liaquat University of Medical & Health Sciences

Section

Original Articles

License

Submission of a manuscript to the journal implies that all authors have read and agreed to the content of the undertaking form or the Terms and Conditions.

When an article is accepted for publication, the author(s) retain the copyright and are required to grant the publisher the right of first publication and other non-exclusive publishing rights to JLUMHS.

Articles published in the Journal of Liaquat University of Medical & health sciences are open access articles under a Creative Commons Attribution-Noncommercial - Share Alike 4.0 License. This license permits use, distribution and reproduction in any medium; provided the original work is properly cited and initial publication in this journal. This is in accordance with the BOAI definition of open access. In addition to that users are allowed to remix, tweak and build upon the work non-commercially as long as appropriate credit is given and the new creations are licensed under the identical terms. Or, in certain cases it can be stated that all articles and content there in are published under creative commons license unless stated otherwise.