Frequency of Skin Disorders in Type 2 Diabetes Mellitus: A Cross-Sectional Study

Authors

  • Razeen Fahad
  • Madiha Soban
  • Saeeda Fouzia Qasim
  • Zubia Aziz
  • Faizah Mughal
  • Fahad Azim

Keywords:

Diabetes Mellitus type II, Skin manifestations, Skin Infections (bacterial /fungal)

Abstract

Objective: To determine the frequency of different Skin Manifestations in people with type II Diabetes Mellitus who visit a tertiary care unit in Karachi, Pakistan.
Methodology: This cross-sectional study was conducted at Liaquat College of Medical & Dentistry & Darul-Sehat Hospital Karachi from July to Nov 2023. A total of 200 patients with Type II Diabetes Mellitus, attending endocrine & dermatology OPD, were enrolled in this study by using consecutive, non-probability sampling techniques. Demographic parameters were noted. Data was analyzed by SPSS version 20.           
Results: Two hundred type II Diabetes Mellitus patients (125 Females and 75 Males) were enrolled in the current study. The mean Age of the patients was 49.62± 10 years, and the mean duration of diabetes was between 6.74± 5.55 years. 115 out of 200 (57.5%) patients showed some skin manifestations. The skin manifestations observed were: Infections (bacterial/fungal) (17.38%), Ulcer & gangrene of foot (6.08%), Pruritis (13.33%), Diabetic dermopathy (10.42%), Foot swelling (7.81), Thick and scaly skin(8.68%), Pigmentation including shin spots (7.81%), Cellulitis (6.07%), Acanthosis nigricans (5.2%), Yellow nails (5.2%), Skin tags(3.46%), Psoriasis (3.46%).
Conclusion: Participants having Diabetes Mellitus type II are found to have a high frequency of skin manifestations (57.5%). The ratio for females was higher than for males. The majority of participants had only one skin manifestation. A noteworthy association was found between higher HbA1c levels (8.1 to 14%) & the presence of cutaneous manifestations.

References

Tomic D, Shaw JE, Magliano DJ. The burden and risks of emerging complications of diabetes mellitus. Nat Rev Endocrinol. 2022; 18(9): 525-39. doi: 10.1038/s41574-022-00690-7. Epub 2022 Jun 6.

Suryasa IW, Rodríguez-Gámez M, Koldoris T. Health and treatment of Diabetes mellitus. Int J Health Sci. 2021; 5(1): 1-5. doi: 10.53730/ijhs.v5n1.2864.

Oguntibeju OO. Type 2 diabetes mellitus, oxidative stress and inflammation: examining the links. Int J Physiol Pathophysiol Pharmacol. 2019; 11(3): 45-63.

Hines A, Alavi A, Davis MD. Cutaneous manifestations of diabetes. Med Clin North AM. 2021; 105(4): 681-97. doi: 10.1016/j.mcna.2021.04.008.

Sanches MM, Roda Â, Pimenta R, Filipe PL, Freitas JP. Cutaneous manifestations of diabetes mellitus and pre-diabetes. Acta Med Port. 2019; 32(6): 459-65. doi: 10.20344/amp.10738.

Henry D, Singh A. A study of pattern of cutaneous manifestations in patients with diabetes mellitus. J Pak Assoc Dermatol. 2020; 30(1): 161-6.

Reschke F, Biester T, Von dem Berge T, Jamiolkowski D, Hasse L, Dassie F et al. Skin manifestations in rare types of diabetes and other endocrine conditions. Endocr Connect. 2023; 12(7): e220410. doi: 10.1530/EC-22-0410.

Chen VY, Siegfried LG, Tomic?Canic M, Stone RC, Pastar I. Cutaneous changes in diabetic patients: primed for aberrant healing? Wound Rep Regener. 2023; 31(5): 700-712. doi: 10.1111/wrr.13108. Epub 2023 Jul 19.

Rodríguez-Rodríguez N, Martínez-Jiménez I, García-Ojalvo A, Mendoza-Mari Y, Guillén-Nieto G, Armstrong DG et al. Wound chronicity, impaired immunity and infection in diabetic patients. MEDICC Rev. 2022; 24(1): 44-58. doi: 10.37757/MR2021.V23.N3.8.

Svoboda SA, Shields BE. Cutaneous manifestations of nutritional excess: Pathophysiologic effects of hyperglycemia and hyperinsulinemia on the skin. Cutis. 2021; 107(2): 74-8. doi: 10.12788/cutis.0173.

Awuchi CG, Echeta CK, Igwe VS. Diabetes and the nutrition and diets for its prevention and treatment: A systematic review and dietetic perspective. Health Sci Res. 2020; 6(1): 5-19.

Gkogkolou P, Böhm M. Skin disorders in diabetes mellitus. JDDG. 2014; 12(10): 847-64. Doi: 10.1111/ddg.12424.

Bhat YJ, Gupta V, Kudyar RP. Cutaneous manifestations of Diabetes mellitus. Int J Diab Dev Ctries. 2006; 26: 152-5.

Ahmed K, Muhammad Z, Qayum I. Prevalence of cutaneous manifestations of Diabetes mellitus. J Ayub Med Coll Abbottabad. 2009; 21(2): 76-9.

Chakrabarty A, Norman RA, Phillips TJ. Cutaneous manifestations of diabetes. In: Diagn Aging Skin Dis. 2008; pp. 253-263. London: Springer London.

Saxena M, Ajula SS. Observational study of cutaneous manifestations among patients of diabetes mellitus. Int J Med Sci Educ. 2021; 8(1): 46-49.

Kumar D, Mehta RD, Ghiya BC, Soni P, Agrawal AM. An epidemiological study of cutaneous manifestations of diabetes mellitus at Tertiary Care Centre of North West Rajasthan (India). Our Dermatol Online. 2022; 13(e): e51. doi: 10.7241/ourd.2022e.51.

Umi?evi?-Šipka S, Balaban J, Bijeli? R. Association between skin manifestations and glycemic control in patients with type 2 diabetes mellitus. Vojnosanitetski pregled. 2021; 78(3): 323-330. doi: 10.2298/VSP190226073U.

Lin C, Liu J, Sun H. Risk factors for lower extremity amputation in patients with diabetic foot ulcers: A meta-analysis. PloS One. 2020; 15(9): e0239236. doi: 10.1371/journal.pone.0239236.

Stancu B, Ilyés T, Farcas M, Coman HF, Chi? BA, Andercou OA. Diabetic foot complications: a retrospective cohort study. Int J Environ Res Public Health. 2022; 20(1): 187. doi: 10.3390/ijerph20010187.

Bose R, Kumar S. Dermatological manifestations in diabetes mellitus. IP Indian J Clin Exper Dermatol. 2020; 6(2): 136-144.

Buckley D. Skin Problems Associated with Diabetes. Textbook of Primary Care Dermatology. 2021: 489-93.

Andamari I, Thio HB, Soebono H. Potential skin problems of diabetes mellitus patients: a review. J Med Sci. 2022; 54(3): 295-307. doi: 10.19106/MedSci005403202211.

Vâ?? D, Stanciu DE, Temelie-Olinici D, Porumb-Andrese E, Tarc?u BM, Grecu VB et al. Cutaneous Manifestations Associated with Diabetes Mellitus - A Retrospective Study. Diseases. 2023; 11(3): 106. doi: 10.3390/diseases11030106.

Garg P, Chandra M. Cutaneous Manifestation of Diabetes mellitus. J Adv Med Dent Sci Res. 2021; 9(5): 100-5.

Verma A, Pandya P, Sharma D. Skin manifestations in patients with type-II diabetes mellitus. Int J Res Rev. 2019; 6(9): 59-65.

Chate A, Swami A, Rane S, Gosavi R. A Cross-Sectional Study to Evaluate Cutaneous Manifestations in Diabetic Patients and their Correlation with Sugar Control at Tertiary Care Center in Western Maharashtra. VIMS Health Sci J. 2021; 8(3): 104-8.

Poorana B, Prasad PV, Kaviarasan PK, Selvamuthukumaran S, Kannambal K. Impact of Glycaemic Control on the Pattern of Cutaneous Disorders in Diabetes Mellitus-A Hospital-Based Case-Control Study. J Clin Diagn Res. 2019; 13(2): WC01-WC05. doi: 10.7860/JCDR/2019/36742.12604.

Downloads

Published

28-06-2024

How to Cite

1.
Fahad R, Soban M, Qasim SF, Aziz Z, Mughal F, Azim F. Frequency of Skin Disorders in Type 2 Diabetes Mellitus: A Cross-Sectional Study. J Liaq Uni Med Health Sci [Internet]. 2024 Jun. 28 [cited 2024 Nov. 22];23(02):155-9. Available from: http://ojs.lumhs.edu.pk/index.php/jlumhs/article/view/1281