Assessment of Serum Lipid and Uric Acid Levels in Women with Normal Pregnancy and Pre-Eclampsia

Authors

  • Beenish Ghaffar
  • Shahida Hassan Memon
  • Feriha Fatima Khidri

Keywords:

Lipid, Pre-eclampsia, Pregnancy, Uric acid

Abstract

OBJECTIVES: To determine and compare the serum lipid profile and uric acid concentration in
pre-eclamptic and normal pregnant women.
METHODOLOGY: This cross sectional study was carried out at Biochemistry Department, LUMHS
Jamshoro with the collaboration of Gynaecology and Obstetrics Department and Diagnostic & Research
Laboratory, Pathology Department, LUMHS Jamshoro from March 2016 to December 2016. Patients were
selected via non-probability consecutive sampling. A total of 60 subjects were enrolled and divided into
two groups comprising women with normal pregnancy(n=30) as controls and women with pre-eclampsia
(n=30) as cases after applying exclusion criteria.
RESULTS: Mean age of women with pre-eclampsia and normal pregnancy was found to be 26.77±2.58
and 26.30±2.05 years (p-value=0.44). Significantly higher levels (p-value < 0.05) of triglycerides (TG), total
cholesterol (TC), low density lipoproteins (LDL) and serum uric acid were found in the women with
pre-eclampsia as compared to controls; whereas, high density lipoproteins (HDL) were significantly
lowered (p-value < 0.05) in women with pre-eclampsia. Uni-variate analysis showed that the TG
(OR=7.67), TC (OR=3 and 5.55), LDL (OR=3.59) and uric acid (OR=11.23) were significantly increased and
HDL (OR= 9.75) were significantly lowered in women with pre-eclampsia than in women with normal
pregnancy (p-value < 0.05). In the multi-variate logistic model, TG (OR=4.28) and uric acid (OR=6.62)
were significantly increased and HDL (OR= 4.31)were significantly lowered in women with pre-eclampsia
than in women with normal pregnancy (p-value<0.05)
CONCLUSION: Alteration in the serum uric acid and TG concentration may be helpful in early detection
and monitoring of pre-eclampsia cases. This information may be utilized in preventing the adverse
outcomes occurring as a result of pre-eclampsia.

Downloads

Published

17-07-2019

How to Cite

1.
Ghaffar B, Memon SH, Khidri FF. Assessment of Serum Lipid and Uric Acid Levels in Women with Normal Pregnancy and Pre-Eclampsia. J Liaq Uni Med Health Sci [Internet]. 2019 Jul. 17 [cited 2024 Dec. 26];18(02):169-74. Available from: http://ojs.lumhs.edu.pk/index.php/jlumhs/article/view/153

Issue

Vol. 18 No. 02 (2019): Journal of Liaquat University of Medical & Health Sciences

Section

Original Articles

License

Submission of a manuscript to the journal implies that all authors have read and agreed to the content of the undertaking form or the Terms and Conditions.

When an article is accepted for publication, the author(s) retain the copyright and are required to grant the publisher the right of first publication and other non-exclusive publishing rights to JLUMHS.

Articles published in the Journal of Liaquat University of Medical & health sciences are open access articles under a Creative Commons Attribution-Noncommercial - Share Alike 4.0 License. This license permits use, distribution and reproduction in any medium; provided the original work is properly cited and initial publication in this journal. This is in accordance with the BOAI definition of open access. In addition to that users are allowed to remix, tweak and build upon the work non-commercially as long as appropriate credit is given and the new creations are licensed under the identical terms. Or, in certain cases it can be stated that all articles and content there in are published under creative commons license unless stated otherwise.