Frequency of Urinary Tract Infection, Microbial Patterns and Drug Resistance in Diabetic Patients in a Tertiary Care Unit

Authors

  • Salma Razzaque
  • Ajeet Kumar
  • Asad Ahmed Khan
  • Masooma Abid
  • Syeda Seemin Raza
  • Ramsha Eraj

Keywords:

Diabetes Miletus, Urinary Tract Infection, E. Coli, Antibiotic Resistance, Aminoglycosides, Quinolones.

Abstract

Objective: To determine the frequency of UTIs in people with diabetes and identify local bacterial flora and antibiotic resistance.

Methodology: An observational, analytical, cross-sectional study was conducted at the Medicine Ward of Jinnah Medical and Dental College Hospital (now Sohail Trust Hospital) from January-December 2020. A convenient sampling technique was applied, and the sample size was 132. Diabetic patients >18 years of age were included. Data was collected on a structured questionnaire. A urine sample was sent for culture sensitivity. Any growing flora and their sensitivity/resistance to antibiotics were recorded. All the data were analysed using SPSS version 21.

Results: UTI was found in 31(23.5%) patients. Female gender, insulin therapy, and lower creatinine clearance were related to UTI, as shown by significant p values. Most common flora was E. Coli 26(84%), followed by Klebsiella 4(13%) and   S. aureus 1(3%). E.Coli was 100% resistant to 3rd generation cephalosporins, 83.9% resistant to quinolones and 67.7% resistant to Penicillin (amoxicillin/clavulanic acid) and 43% resistant to aminoglycosides. Klebsiella was 100% resistant to Penicillin and quinolones and 85% to 3rd generation cephalosporin. E. coli and Klebsiella were 100% sensitive to carbapenems, nitrofurantoin and Fosfomycin, whereas S. Aureus was resistant to cloxacillin, clindamycin and clindamycin and quinolones, while sensitive to vancomycin., linezolid and aminoglycosides.

CONCLUSION: UTI was found in 23.5% of our diabetic patients; the most common organisms prevalent were E. Coli, Klebsiella and S. aureus, which was primarily resistant to Penicillins, Cephalosporins and quinolones while sensitive to nitrofurantoin, Fosfomycin and carbapenems.

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Published

21-06-2023

How to Cite

1.
Razzaque S, Kumar A, Khan AA, Abid M, Raza SS, Eraj R. Frequency of Urinary Tract Infection, Microbial Patterns and Drug Resistance in Diabetic Patients in a Tertiary Care Unit. J Liaq Uni Med Health Sci [Internet]. 2023 Jun. 21 [cited 2024 Dec. 10];22(02):99-103. Available from: http://ojs.lumhs.edu.pk/index.php/jlumhs/article/view/971