Association of Vitamin D Deficiency with Early Onset of Osteoarthritis

Authors

  • Nusrat Rasheed
  • Asadullah Makhdoom
  • Muhammad Shafiq Khan
  • Naseem Rasheed
  • Muhammad Hassan Khan

Abstract

Objective: To evaluate the association of serum vitamin D deficiency and early onset of osteoarthritis (OA) knee joints.
Methodology: This single-blinded comparative OPD based study, conducted at Dow University Hospital, Karachi. Patients <40 years of age having knee pain for the last six months were included. Osteoarthritis was classified according to the Kellgren Lawrence(KL) scale. Randomization was done, dividing the patients in two groups. One with normal vitamin D level whereas the other group had low levels of vitamin D. Both groups were compared based on X-ray findings to evaluate the association of OA with vitamin D deficiency.
RESULTS: In our study, out of 152 patients, 106 were diagnosed with Osteoarthritis. The mean age was 36.84 years. Serum calcium level normal in 100 (65.8%) patients. Based on radiological findings, 75 (49.3%) were KL grade 1 while 31 (20.4%) were grade 2, 75 (49.3%) had right-sided knee involvement. In the group with low levels of serum vitaminD, 32 (40%) had right knee affected, 25 (31.3%) had left, 20 (25%) had bilateral knee involvement, whereas three had normal knee joints The Chi-square test showeda positive relationship between low levels of vitamin D and osteoarthritis.
Conclusion: The above study shows statisticaly significant association between vitamin  D deficiency and early onset of osteoarthritis. Cartilage loss and radiographic progression of the disease are important factors to understand the disesease pathogienesis. Therapeutic or preventive role of vitamin D in osteoarthritis may be established but for that long term studies are needed.

Keywords: Osteoarthritis, Vitamin D, Kellgren Lawrence scale, BMI.

Downloads

Published

31-12-2020

How to Cite

1.
Rasheed N, Makhdoom A, Khan MS, Rasheed N, Khan MH. Association of Vitamin D Deficiency with Early Onset of Osteoarthritis. J Liaq Uni Med Health Sci [Internet]. 2020 Dec. 31 [cited 2024 Dec. 23];19(04):267-70. Available from: http://ojs.lumhs.edu.pk/index.php/jlumhs/article/view/492

Issue

Vol. 19 No. 04 (2020): Journal of Liaquat University of Medical & Health Sciences

Section

Original Articles

License

Submission of a manuscript to the journal implies that all authors have read and agreed to the content of the undertaking form or the Terms and Conditions.

When an article is accepted for publication, the author(s) retain the copyright and are required to grant the publisher the right of first publication and other non-exclusive publishing rights to JLUMHS.

Articles published in the Journal of Liaquat University of Medical & health sciences are open access articles under a Creative Commons Attribution-Noncommercial - Share Alike 4.0 License. This license permits use, distribution and reproduction in any medium; provided the original work is properly cited and initial publication in this journal. This is in accordance with the BOAI definition of open access. In addition to that users are allowed to remix, tweak and build upon the work non-commercially as long as appropriate credit is given and the new creations are licensed under the identical terms. Or, in certain cases it can be stated that all articles and content there in are published under creative commons license unless stated otherwise.