Diffuse Large B Cell Lymphoma: International Prognostic Scoring System Risk Stratification at A Tertiary Care Center in Punjab
Keywords:
Diffuse large B Cell Lymphoma, LDH, IPSS.Abstract
OBJECTIVE: To stratify the patients according to international prognostic system and to compare our
outcome with international data for Diffuse large B cell lymphoma disease.
METHODOLOGY: It was a descriptive cross sectional study carried out from 2014 to 2018 at Hematology
section of Pathology Department, King Edward Medical University, Lahore. Patients were selected by
non- randomized purposive sampling. Eighty (80) patients diagnosed by histopathology and immunohistochemistry
on
lymph
node
biopsy
were
enrolled
and data was analyzed for qualitative and quantitative
variables such as age, gender, B symptoms, type of lymph node and extranodal site involved, complete
blood count (CBC), bone marrow examination findings, Ann Arbor stage and serum LDH.
RESULTS: Out of 80 patients, majority were males (51) with M: F ratio of 1.75:1. Median age at diagnosis
was 49.5±16.44 year. 18.75% had B symptoms at the time of the diagnosis. Mediastinal involvement was
seen in 11.25% patients while LDH level was elevated in 96.25%. By applying IPSS, 41.25%, 23.75%,
27.5% and 7.5% were categorized into low, low/intermediate, intermediate/high and high risk groups
respectively.
CONCLUSION: Majority of our patients presented as Low risk category followed by intermediate/high
risk group. High risk group was the least frequently encountered one. The pattern is similar to
international data except intermediate/high risk category being the second most common category in
our patients.
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