Prevalence of haemoglobinopathies in children presenting with anemia at DHQ Hospital Zhob, Balochistan

Authors

  • Sumera Akram DHQ Hospital Zhob
  • Saeed Akhtar Khan Khattak
  • Muhammad Ahmed Khan Cmh
  • Syed Asad ali
  • Muhammad Ameen Khan

Abstract

Objective: To find the prevalence of haemoglobinopathies in children presenting with anemia at District Headquarter Hospital Zhob.

Methodology: The cross-sectional study was carried out at District Headquarter Hospital (DHQ) Zhob from March to August 2021. Patients aged 6 months to 15 years presented with signs and symptoms of anemia were included in the study and investigated for haemoglobinopathies through complete blood count, peripheral smear, iron studies (serum ferritin), haemoglobinanalysis by haemoglobinelectrophoresis, high-performance liquid chromatography and sickling test. All the data, including age, gender, and diseases was recorded and analyzed with the help of a statistical package for social sciences (SPSS 21).

Results: A total of 2258 children were clinically suspected of anemia and were advised the sequential blood tests for diagnosing Haemoglobinopathies. Out of these, 239 cases lost to follow up. The remaining 2019 cases were included, comprising1026 males (50.81%) and 993 females (49.18%) with a mean age 8.09±3.78 years. Haemoglobinopathies constituted 8.9%ofpediatric diseases and 56.7% of anemia cases. The most common haemoglobinopathy was beta-thalassemia major (29.4%), followed by sickle / beta-thalassemia compound heterozygous (28.3%), sickle cell disease (28%), HbH “alpha thalassemia” (2.8%), HbD trait (2.3%), HbE/Beta-thalassemia (2%), HbD Homozygous  (1.8%), HbD/beta-thalassemia (1.5%), HbE trait (1.1%) and Beta-thalassemia minor (0.9%). There were 11 cases (1%) reports labeled as borderline.

Conclusion: Haemoglobinopathies constitute a major portion of diseases and the most common cause of anemia in the pediatric population of Zhob.

 Keywords: Haemoglobinopathy, anemia, Thalassemia, Vitamin B12, Folate, Iron deficiency anemia

Downloads

Published

03-01-2022

How to Cite

1.
Akram S, Khan Khattak SA, Khan MA, ali SA, Khan MA. Prevalence of haemoglobinopathies in children presenting with anemia at DHQ Hospital Zhob, Balochistan. J Liaq Uni Med Health Sci [Internet]. 2022 Jan. 3 [cited 2024 Nov. 24];20(5):314-8. Available from: http://ojs.lumhs.edu.pk/index.php/jlumhs/article/view/678

Issue

Vol. 20 No. 5 (2021): Journal of Liaquat University of Medical & Health Sciences

Section

Original Articles

License

Copyright (c) 2022 Journal of Liaquat University of Medical & Health Sciences

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Submission of a manuscript to the journal implies that all authors have read and agreed to the content of the undertaking form or the Terms and Conditions.

When an article is accepted for publication, the author(s) retain the copyright and are required to grant the publisher the right of first publication and other non-exclusive publishing rights to JLUMHS.

Articles published in the Journal of Liaquat University of Medical & health sciences are open access articles under a Creative Commons Attribution-Noncommercial - Share Alike 4.0 License. This license permits use, distribution and reproduction in any medium; provided the original work is properly cited and initial publication in this journal. This is in accordance with the BOAI definition of open access. In addition to that users are allowed to remix, tweak and build upon the work non-commercially as long as appropriate credit is given and the new creations are licensed under the identical terms. Or, in certain cases it can be stated that all articles and content there in are published under creative commons license unless stated otherwise.