Subclinical hypothyroidism association with lipid metabolism disturbance and oxidative stress

Authors

  • Zaib-Un-Nisa Mughal
  • Jawaid Ahmed Zai
  • Nazia Parveen Gill
  • Latafat Ali Chughtai
  • Aftab Ahmed Khand
  • Asma Soomro

Abstract

OBJECTIVE: To evaluate the lipid disturbance and oxidative stress in females with subclinical hypothyroidism.

METHODOLOGY: This case-control study was conducted at the Department of the Physiology University of Sindh, Jamshoro from April – September 2018.  A total of 80 females were selected by random technique and were divided into two groups. Subjects with a history of episodic higher TSH discordant to FT4 levels and current levels of TSH ranging between 4.5mI U/L-<10mI U/L were selected for the study, subjects with hormone replacement therapy, chronic diseases or medication, pregnancy, or smoking habits were excluded. Thyroid profile (TSH, fT4), lipid profile (LDL, HDL, triglyceride, and total cholesterol), oxidative stress markers (MDA, AOPP, ABTS assay, CAT, SOD, GSH, and NO), and C reactive proteins were investigated and compared in subclinically hypo thyroid’s females (SCH) with controls (Cont) females reside in Hyderabad Sindh, Pakistan. SPSS (statistical package for the social sciences) version 20.0 was used for statistical analysis.

RESULTS: We observed SCH group subjects with elevated TSH (7.41±0.23) having a slight increase in their LDL (116.39±2.52) and triglyceride levels (122.75±4.74), and also showing elevated MDA (2.49±0.17), AOPP (91.25±1.98) level, but had decreased level of GSH (119.33±2.19). However, no significant difference has been found in CAT, SOD, NO, and C - reactive protein between the two groups.

CONCLUSION: Observations of present studies suggestive of disturbed lipid metabolism in subclinically hypothyroid’s females and a burdened antioxidants status.

 KEYWORDS: Lipid Profile, Thyroid profile, Oxidative Stress markers, Subclinical hypothyroidism, C reactive protein.

Downloads

Published

04-01-2022

How to Cite

1.
Mughal Z-U-N, Zai JA, Gill NP, Chughtai LA, Khand AA, Soomro A. Subclinical hypothyroidism association with lipid metabolism disturbance and oxidative stress. J Liaq Uni Med Health Sci [Internet]. 2022 Jan. 4 [cited 2024 Nov. 22];20(5):329-34. Available from: http://ojs.lumhs.edu.pk/index.php/jlumhs/article/view/510

Issue

Vol. 20 No. 5 (2021): Journal of Liaquat University of Medical & Health Sciences

Section

Original Articles

License

Copyright (c) 2022 Journal of Liaquat University of Medical & Health Sciences

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Submission of a manuscript to the journal implies that all authors have read and agreed to the content of the undertaking form or the Terms and Conditions.

When an article is accepted for publication, the author(s) retain the copyright and are required to grant the publisher the right of first publication and other non-exclusive publishing rights to JLUMHS.

Articles published in the Journal of Liaquat University of Medical & health sciences are open access articles under a Creative Commons Attribution-Noncommercial - Share Alike 4.0 License. This license permits use, distribution and reproduction in any medium; provided the original work is properly cited and initial publication in this journal. This is in accordance with the BOAI definition of open access. In addition to that users are allowed to remix, tweak and build upon the work non-commercially as long as appropriate credit is given and the new creations are licensed under the identical terms. Or, in certain cases it can be stated that all articles and content there in are published under creative commons license unless stated otherwise.