Relationship of Serum Prostate Specific Antigen with Hirsutism in Women Having Polycystic Ovary Syndrome Belonging to the Province of Khyber Pakhtunkhwa, Pakistan

Authors

  • Naheed Khattak
  • Sadaf Durrani
  • Sobia Ali
  • Kalsoom Tariq
  • Ubaid ur Rahman
  • Mudassir Ahmad Khan

Keywords:

Prostate Specific Antigen, Hirsutism, Polycystic Ovary Syndrome

Abstract

Objective: To find the relationship of serum PSA with Hirsutism in PCOS females of Khyber Pakhtunkhwa.

Methodology: It was a cross-sectional/comparative study. This study was conducted in Khyber Teaching Hospital, Lady Reading Hospital, and Hayatabad Medical Complex from June to December 2021. A total of 172 study subjects were involved in this study. Serum PSA, testosterone and DHEAS levels of 86 newly diagnosed cases of PCOS (Group A) were compared with 86 healthy age-matched controls (Group B). These parameters were estimated using the ELISA method. Distribution of Hirsutism of the study subjects was also established with FGS. SPSS version 21 was used to analyze the data.

Results: The results showed that serum PSA significantly increased (0.325±0.243 Vs 0.119±0.209, P <0.0001) in females with PCOS. Serum total testosterone (1.639±0.773 vs 0.739±0.965, P<0.0001) and DHEAS (3.397±1.243 Vs 2.035±1.203, P <0.0001) levels were also raised. A highly significant positive relationship was seen between PSA with Hirsutism through FGS (r 0-609, P 0.000), testosterone (r 0.352, P 0.000) and DHEAS levels (r 0.432, P 0.000)

Conclusion: This study observed significantly high PSA correlating positively with Hirsutism in females with PCOS.

Keywords: Prostate Specific Antigen, Hirsutism, Polycystic Ovary Syndrome

References

Goodarzi MO, Dumesic DA, Chazenbalk G, Azziz R. Polycystic ovary syndrome: etiology, pathogenesis and diagnosis. Nat Rev Endocrinol. 2011; 7(4): 219-231. doi: 10.1038/nrendo.2010. 217. Epub 2011 Jan 25.

Teede HJ, Misso ML, Costello MF, Dokras A, Laven J, Moran L et al. Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome. Fertil Steril. 2018; 110(3): 364-379. doi: 10.1016/j.fertnstert.2018.05.004. Epub 2018 Jul 19.

Azziz R, Carmina E, Chen Z, Dunaif A, Laven JS, Legro RS et al. Polycystic ovary syndrome. Nat Rev Dis Primers. 2016; 2: 16057. doi: 10.1038/nrdp.2016.57.

Horowitz E, Weissman A. The stair-step approach in treatment of anovulatory PCOS patients. Ther Adv Reprod Health. 2020; 14: 26334941209088 18. doi: 10.1177/2633494120908818.

Hanamura T, Ohno K, Hokibara S, Murasawa H, Nakamura T, Watanabe H et al. Clinical significance of serum PSA in breast cancer patients. BMC Cancer. 2019; 19(1): 1021.

doi: 10.1186/s12885-019-6256-2.

Musrap N, Diamandis EP. Prostate-specific antigen as a marker of Hyperandrogenism in omen and its implications for antidoping. Clin Chem. 2016; 62(8): 1066-74. doi: 10.1373/clinchem.2016.256198. Epub 2016 Jun 3.

Tsilchorozidou T, Overton C, Conway GS. The pathophysiology of polycystic ovary syndrome. Clin. Endocrinol. 2004; 60(1): 1-17. doi: 10.1046/j. 1365-2265.2003.01842.

Spritzer PM, Barone CR, Oliveira FB. Hirsutism in polycystic ovary syndrome: pathophysiology and management. Curr Pharm Des. 2016; 22(36): 5603-13. doi: 10.2174/1381612822666160720151 243.

Randall VA. Androgens and hair growth. Dermatol. Ther. 2008; 21(5): 314-28.

doi: 10.1111/j.1529-8019.2008.00214.x.

Yildiz BO, Bolour S, Woods K, Moore A, Azziz R. Visually scoring Hirsutism. Hum Reprod Update. 2009; 16(1): 51-64. doi: 10.1093/humupd/dmp 024.

Ilagan MKCC, Paz-Pacheco E, Totesora DZ, Clemente-Chua LR, Jalique JRK. The Modified Ferriman-Gallwey Score and Hirsutism among Filipino Women. Endocrinol Metab(Seoul). 2019; 34(4): 374-381. doi: 10.3803/EnM.2019.34.4.374.

Ferriman D, Gallwey JD. Clinical assessment of body hair growth in women. J Clin Endocrinol Metab. 1961; 21(11): 1440-7. doi: 10.1210/jcem-21-11-1440.

Spritzer PM, Marchesan LB, Santos BR, Fighera TM. Hirsutism, normal androgens and diagnosis of PCOS. Diagnostics (Basel). 2022; 12(8): 1922. doi: 10.3390/diagnostics12081922.

Kurtoglu G, Emre S, Metin A, Ergin M, Erel O, Aktas A. Serum prostate-specific antigen levels in women with androgenic alopecia. Turkderm-Turk Arch Dermatol Venereology 2019; 53: 1-6. doi: 10.4274/turkderm.galenos.2018.25492.

Nadir A, Temikan S, Ozderya A, Temizkan O, Orbay E, Aydin K. Dehydroepiandrosterone sulphate/ free androgen index ratio predicts a favorable metabolic profile in patients with polycystic ovary syndrome. Gynecol Endocrinol. 2019; 35(2): 128-132. doi: 10.1080/09513590. 2018.1505843. Epub 2018 Oct 16.

Banu H, Hasanat MA, Akhtar N, Shah S, Sultana T, Tuqan S et al. Prostate specific antigen is raised in polycystic ovary syndrome. Endocrinol Metab Int J. 2018; 6(4): 297-300. doi: 10.15406/emij.2018.06.00192.

ZH Wu, Y Tang, X Niu, FF Pu, XY Xiao, W Kong. Prostatic-specific antigen (PSA) levels in patients with polycystic ovary syndrome (PCOS): a meta-analysis. Wu ZH, Tang Y, Niu X, Pu F, Xiao XY, Kong W. J Ovarian Res. 2019; 12: 94. doi: 10.1186/s13048-019-0569-2.

Radowicki S, Kunicki M, Bandurska-Stankiewicz E. Prostate-specific antigen in the serum of women with benign breast disease. Eur J Obstet Gynecol Reprod Biol. 2008; 138(2): 212-6. doi: 10.1016/j.ejogrb.2007.05.023. Epub 2007 Sep 11.

Duraker N, Can D, Parilti M. Measurement of serum total and free prostate specific antigen in women with colorectal carcinoma. Br J Cancer. 2002; 86(2): 203-6. doi: 10.1038/sj.bjc.6600049.

Vural B, Ozkan S, Bodur H. Is prostate-specific antigen a potential new marker of androgen excess in polycystic ovary syndrome? J Obstet Gynaecol Res. 2007; 33(2): 166-73. doi: 10.1111/j.1447-0756.2007.00507.x.

Ibrahim WW, Salah RK, Abbas WM. Serum prostate specific antigen level in women with polycystic ovary syndrome. Fac Med Baghdad. 2016; 58(2): 136-9.

Ukinc K, Ersoz HO, Erem C, Hacihasanoglu AB. Diagnostic value of prostate-specific antigen (PSA) and free prostate-specific antigen (fPSA) in women with ovulatory and anovulatory polycystic ovary syndrome. Endocrine. 2009; 35(1): 123-9. doi: 10.1007/s12020-008-9130-6. Epub 2008

Nov 14.

Rudnicka E, Radowicki S, Suchta K. Prostate-specific antigen (PSA) in diagnosis of polycystic ovarian syndrome a new insight. Gynecol Endocrinol. 2016; 32(11): 931-5. doi: 10.1080/ 09513590.2016.1200552. Epub 2016 Jul 16.

Tokmark A, Bodur S, Erkilinc S, Ozel S, Engin-Ustun Y. The value of prostate-specific antigen in diagnosis of polycystic ovarian syndrome in adolescent girls. J Pediatr Adolesc Gynecol. 2018; 31(3): 263-9. doi: 10.1016/j.jpag.2017.11.004. Epub 2017 Nov 21.

Nagaraj S, Naik AL, Pratibha K, Kumar VK. Prostate specific antigen in women with PCOS and its correlation with total testosterone. Int J Biotech Biochem. 2019; 15(2): 87-95.

Bhat K, Bhandari M, Garg V. Prostate specific antigen: a diagnostic marker in polycystic ovarian syndrome. J Clin Diagnostic Res. 2019; 13(1): BC14-BC16.

Downloads

Published

2023-06-21

How to Cite

1.
Khattak N, Durrani S, Ali S, Tariq K, ur Rahman U, Khan MA. Relationship of Serum Prostate Specific Antigen with Hirsutism in Women Having Polycystic Ovary Syndrome Belonging to the Province of Khyber Pakhtunkhwa, Pakistan. J Liaq Uni Med Health Sci [Internet]. 2023 Jun. 21 [cited 2024 Jun. 20];22(02):94-8. Available from: http://ojs.lumhs.edu.pk/index.php/jlumhs/article/view/1030