Diagnostic Utility of Bone Marrow Biopsy/ Bone Marrow Culture in Pyrexia of Unknown Origin: A Ten-Year Retrospective Analysis


  • Sehar Khaliq
  • Haider Ali


Pyrexia, Bone marrow biopsy, Bone Marrow Culture, PUO, Bone Marrow Aspirate, Mycobacterium Tuberculosis


Objective: This study was carried out to assess the diagnostic utility of BMB and BMC in patients with PUO.

Methodology: This retrospective cross-sectional study was conducted at Fauji Foundation Hospital, Rawalpindi. The clinical, laboratory and radiological records from January 2012 - December 2021 were retrieved from our hospital management information system for this study. Data from 63 patients with PUO were analyzed according to Petersdorf criteria.

Results: Out of 63 patients with PUO, BMB was diagnostic in 25 (39.68%) patients. The leading cause of PUO was infectious disorders (mycobacterium tuberculosis, visceral leishmaniasis, malaria), followed by inflammatory disorders and hematological malignancies. In 38 (60.31%) patients, BMB could not detect any underlying pathology. BMC showed growth in only 03(4.76%) patients, and the diagnostic yield of BMC was meagre.

Conclusion: BMB is essential in establishing a diagnosis in patients with PUO. Infectious diseases are the leading cause of PUO, and BMC should not be included as a routine investigation in the initial evaluation of a patient with PUO.



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How to Cite

Khaliq S, Ali H. Diagnostic Utility of Bone Marrow Biopsy/ Bone Marrow Culture in Pyrexia of Unknown Origin: A Ten-Year Retrospective Analysis. J Liaq Uni Med Health Sci [Internet]. 2023 Mar. 29 [cited 2023 May 30];22(01):40-3. Available from: http://ojs.lumhs.edu.pk/index.php/jlumhs/article/view/1007