LIAQUAT MEDICAL RESEARCH JOURNAL http://ojs.lumhs.edu.pk/index.php/LMRJ <p>Liaquat Medical Research Journal (LMRJ) is a Gold Openaccess Journal, publishes basic, clinical and para-clinical aspects of medical sciences including Anatomy, Biochemistry, Biotechnology, Physiology, Pharmacology, Parasitology, Hematology, Microbiology, Radiotherapy, Radiobiology, Medical Imaging, Medical Informatics, Medical Physics, Nutrition, Virology, and any animal experimental studies in the form of original articles, reviews and case reports.</p> Liaquat University of Medical & Health Sciences en-US LIAQUAT MEDICAL RESEARCH JOURNAL 2664-5734 <p>Copyright: Open access journal copyright lies with authors and protected under CC BY-NC-ND 4.0 licence (https://creativecommons.org/licenses/by-nc-nd/4.0/).</p> Induced pluripotent stem cells for development of cancer immunotherapy - A viable idea for less toxic treatment http://ojs.lumhs.edu.pk/index.php/LMRJ/article/view/938 <p>Induced pluripotent stem cells were introduced by Prof. Yamanaka and now being studied in all stem cells related treatment methods. Cancer immunotherapy is now part of targeted therapy and showing promising results, however the cost of treatment and tagged risk of side effects making it difficult for patients. Thus use of induced pluripotent stem cells to grow into plasma cells and produce antibodies against cancer targets will be a breakthrough in cancer management</p> <p>&nbsp;</p> Prof. Binafsha Manzoor Syed Copyright (c) 2022 Dr. Binafsha Manzoor Syed https://creativecommons.org/licenses/by-nc-nd/4.0 2022-06-29 2022-06-29 4 2 10.38106/LMRJ.2022.4.2-01 Posterior Reversible Encephalopathy Syndrome with Blood Transfusion? http://ojs.lumhs.edu.pk/index.php/LMRJ/article/view/883 <p>Posterior Reverse Encephalopathy Syndrome (PRES) is a clinico-neuro-radiologic entity with various neurological manifestations, including headaches, vision problems, and altered mental status. Oedema has been observed in a generally symmetrical fashion in MRI studies, most often in the subcortical white matter and rarely in the cortex of the occipital and parietal lobes. When properly treated, this condition is usually reversible; however, failure to make a timely diagnosis may result in cerebral infarction and even death. This case report presents a 30-year-old woman with a history of postpartum bleeding and anuria, later diagnosed with PRES syndrome. This rare case is reported here for information of neurology clinicians to keep the features in mind if any such case comes up in future.</p> Mukesh Kumar Pooran Mal Sunil Aqsa Copyright (c) 2022 Mukesh Kumar, Dr. Pooran Mal, Dr. Sunil, Dr. Aqsa https://creativecommons.org/licenses/by-nc-nd/4.0 2022-06-29 2022-06-29 4 2 10.38106/LMRJ.2022.4.2-07 Hyperprolectinemia in newlyHyperprolectinemia in newly diagnosed Breast cancer in younger (<50) women diagnosed Breast cancer in younger (<50) women http://ojs.lumhs.edu.pk/index.php/LMRJ/article/view/933 <p>Breast cancer is a common malignancy among women. There are a number of established risk factors for breast cancer in younger population. Hyperprolactinemia is observed to be higher in breast cancer patients. However its presentation in younger (&lt;50 years) women is not well understood. This study was conducted to describe serum prolactin level in newly diagnosed breast cancer patients presented with nipple discharge without any apparent other cause of hyperprolactinemia. The results showed high serum prolactin levels in all these patients. There was no significant correlation observed between serum prolactin and the age of the patients.</p> <p>It was concluded that breast cancer patients presenting with nipple discharge show varying degree of hyperprolactinemia. It requires further studies to explore if it has a causal relationship or it is a feature of breast cancer.</p> Jawaid Naeem Qureshi K. Altaf Hussain Talpur Copyright (c) 2022 Jawaid Naeem Qureshi, K. Altaf Hussain Talpur https://creativecommons.org/licenses/by-nc-nd/4.0 2022-06-29 2022-06-29 4 2 10.38106/LMRJ.2022.4.2-02 Hemostatic and thrombotic parameters in acure leukemia- A comparison of pre and post remission induction phase http://ojs.lumhs.edu.pk/index.php/LMRJ/article/view/907 <p>This study was aimed to compare hemostatic, fibrinolytic and thrombotic parameters in pre and post induction chemotherapy in acute myeloid leukemia (AML) and acute lymphoid leukemia (ALL). A total of 110 diagnosed acute leukemia patients and 40 normal individuals were enrolled in the study. Questionnaire were filled and patients’ blood specimens were collected before the commencement and post induction chemotherapy. Prothrombin time (PT), activated partial thromboplastin time (aPTT), von Willebrand factor antigen (vWF Ag), fibrinogen level, factor VIIIc (FVIIIc), D-Dimers, fibrinogen degradation products (FDPs), anti-thrombin III (AT), lupus anticoagulant (LA), protein C (PC), protein S and diluted russel viper venom test (DRVVT) were conducted in all the participants. A significant rise was identified in post-induction levels of PT, aPTT, vWF Ag, fibrinogen and factor VIII in acute leukemia patients. Analysis of fibrinolytic markers indicated increased D-Dimers and plasminogen levels while the levels of alpha 2 anti-plasmin were reduced in pretreated patients. Thrombotic markers’ assessment showed increased levels of AT and LA while decreased level of PC in pretreated acute leukemia patients. It was concluded that remission induction chemotherapy, in acute leukemia patients, significantly affects the coagulation, fibrinolytic and thrombotic parameters.</p> Tehmina Nafees Sonia Khan Tariq Masood Zara tul ain Bashir Tasneem Farzana Abdul Sattar Tahir Shamsi Copyright (c) 2022 Tehmina Nafees Sonia Khan, Tariq Masood, Zara tul ain Bashir, Tasneem Farzana, Abdul Sattar, Tahir Shamsi https://creativecommons.org/licenses/by-nc-nd/4.0 2022-06-29 2022-06-29 4 2 10.38106/LMRJ.2022.4.2-03 Night time splinting without surgery for dupuytren’s contracture – a successful case series of elderly diabetic patients http://ojs.lumhs.edu.pk/index.php/LMRJ/article/view/942 <p>Dupuytren’s contracture is a musculoskeletal deformity mainly involves fingers of the hands. Elderly diabetic patients more frequently suffer from the problem. Currently available options of treatment include needling, clostridium histolyticum injection and surgery. Following surgery patients are supposed to apply splint to correct the contracture. This study was conducted on early stage contracture, including 18 patients. All were advised to massage the area of contracture in the morning and at night followed by application of splint at night time. 16 patients showed complete recovery with average duration of 3.5 weeks. None of them has recurrence after three weeks of follow-up. The study concludes that the early stage contracture can be successfully treated by conservative measures</p> Asim Niaz Channa Sana Shahzad Faisal Jamil Copyright (c) 2022 Asim Niaz Channa, Sana Shahzad, Faisal Jamil https://creativecommons.org/licenses/by-nc-nd/4.0 2022-06-29 2022-06-29 4 2 10.38106/LMRJ.2022.4.2-04 The Assessment of macular function in dense cataract using Maddox rod http://ojs.lumhs.edu.pk/index.php/LMRJ/article/view/823 <p>Cataract is a leading cause of blindness worldwide. However there is surgical option available for treatment with complete cure in majority of patients. For dense cataract Maddox Rod was evaluated. A total of 200 patients were recruited. Maddox Rod test for macular function appears to be useful in a great majority of patients. The assessment of macular function in dense cataract is difficult but the Psycho physiological test like Maddox rod test was found to be the reliable in patients with cataract and its quick and understandable</p> Muhammad Asif Memon Ayesha Kazmi Mehak Nazeer Abdul Hameed Talpur Muhammad Munawar Humudullah Copyright (c) 2022 Muhammad Asif Memon, Ayesha Kazmi, Mehak Nazeer, Abdul Hameed Talpur, Muhammad Munawar, Humudullah https://creativecommons.org/licenses/by-nc-nd/4.0 2022-06-29 2022-06-29 4 2 10.38106/LMRJ.2022.4.2-05 Analysis of pattern of ABO Blood groups in pediatric diabetic patients – An observational study http://ojs.lumhs.edu.pk/index.php/LMRJ/article/view/912 <p>Diabetes Mellitus (DM) is the most frequently occurring metabolic disorder, caused by inadequacy in secretion of insulin or malfunction leading to chronic hyperglycemia. Well-established corroborations have been reported in the literature suggesting association of ABO blood group with DM. The available literature focuses on adult population, with limited information of said association in children. Thus this study was aimed to determine the association of ABO blood group with Diabetes in pediatric patients having confirmed diagnosis. This was a comparative cross sectional study conducted from October 2021-January 2022 at Endocrinology Ward, Children Hospital Lahore (CHL), Pakistan. The study was approved by the local research ethics committee of CHL and conducted according to the declaration of Helsinki 2000. Blood grouping was done by forward and reverse methods. A total of 25 patients, including 18 males and 7 females were included. Frequency of blood group B (n=10;40%) was highest followed by blood group O (n=4;16%), A blood group (n=3;12%), and AB (n=1;4%) in males. In females, the blood group AB (n=3;12%) has the highest frequency followed by O (n=2;8%). Blood group A (n=1;4%) and B (n=1;4%) had the same frequency among female diabetic patients</p> Nimra Javed Shazia Yasin Javeria Fatima Tehmina Nafees Sonia Khan Tooba Fateen Nazish Saqlain Saima Farhan Copyright (c) 2022 Nimra Javed, Shazia Yasin, Javeria Fatima, Tehmina Nafees Sonia Khan, Tooba Fateen, Nazish Saqlain, Saima Farhan https://creativecommons.org/licenses/by-nc-nd/4.0 2022-06-29 2022-06-29 4 2 10.38106/LMRJ.2022.4.2-06